The U.S. stocks fell on Wednesday after the employment data of private sector and regional manufacturing data disappointed the investors.

ADP reported that private sector employers slashed 23,000 jobs in March, missing expectations for an increase of about 40,000 jobs. And the February data were adjusted to 24,000 job losses from the originally reported 20,000. The ADP report is regarded as an indicator of the Labor Department's employment report due out Friday.

Major indexes moved further lower after the worse-than-expected Chicago PMI reading. The regional manufacturing index slipped to 58.8 in March from 62.6 in the previous month, while economists had expected a smaller drop to 61.

Meanwhile, factory orders for manufactured goods rose 0.6 percent in February, slightly higher than analysts' expectations but significantly less than January's 2.5-percent increase.

The Dow Jones industrial average fell 50.79, or 0.47 percent, to 10,856.63. The Standard & Poor's 500 index dipped 3.84, or 0.33 percent, to 1,169.43 and the Nasdaq lost 12.73, or 0.53 percent, to 2,397.96.